Mehmet Sen
Harvard Medical School, United States
Biography
Mehmet Sen has completed his PhD from the University of Houston, Department of Biology and Biochemistry with Glen Legge, M.D., Ph.D., and postdoctoral studies from Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology with Timothy Alan Springer, Ph.D.. His research interests lie in the structural and functional basis of receptor/ligand interactions, which are relevant to human health and disease. Structural studies by protein NMR spectroscopy, X-ray Crystallography and Electron microscopy are complemented by functional approaches using molecular biology and protein engineering to dissect structural information, design proteins/peptides/small molecules with modified specificities and activities, and ultimately contributes to the development of biologics with therapeutic potential.
Abstract
Abstract : Structural alterations of leukocyte integrin, LFA-1