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4th International Conference on Synthetic Biology and Tissue Engineering, will be organized around the theme “Design and construct new biological parts for novel functions”

Synthetic Biology 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Synthetic Biology 2018

Submit your abstract to any of the mentioned tracks.

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Systems and Synthetic Biology is a relatively new field in biomedical research. It focuses on engineering new or modified signaling proteins to create desired signaling pathways in the cell. Every living cell is an extremely complex machine expressing thousands of different proteins. Due to superb regulation, many cells, such as photoreceptors and other neurons in vertebrates, can live for decades. Cells can also self-reproduce by division, where both daughter cells are perfectly viable. Natural selection (the “blind watchmaker”, to use Dawkins’ expression) spent hundreds of millions of year to achieve this perfection. Due to elucidation of the intricacies of cellular regulatory mechanisms we can now play evolution on our time scale: re-design proteins and signaling pathways to achieve our ends.

  • Track 1-1Systems Biology
  • Track 1-2Gene Signaling
  • Track 1-3Genome Design
  • Track 1-4 Bioprocessing Engineering
  • Track 1-5Cell Growth and Cell Culture

Synthetic biology is the convergence of advances in chemistry, biology, computer science, and engineering that enables us to go from idea to product faster, cheaper, and with greater precision than ever before. It can be thought of as a biology-based “toolkit” that uses abstraction, standardization, and automated construction to change how we build biological systems and expand the range of possible products. A community of experts across many disciplines is coming together to create these new foundations for many industries, including medicine, energy and the environment.

Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological tissues. Tissue engineering involves the use of a scaffold for the formation of new viable tissue for a medical purpose. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own.

CRISPR-Cas9 is a unique technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the DNA Sequence.It is currently the simplest, most versatile and precise method of genetic manipulation and is therefore causing a buzz in the science world.

The CRISPR-Cas9 system consists of two key molecules that introduce a change (mutation) into the DNA. These are an enzyme Called Cas9. This acts as a pair of ‘molecular scissors’ that can cut the two strands of DNA and a piece of RNA Called guide RNA (gRNA) which binds to DNA. The Cas9 follows the guide RNA to the same location in the DNA sequence and makes a cut across both strands of the DNA. At this stage the cell recognises that the DNA is damaged and tries to repair it.

  • Track 4-1CRISPR-Cas9 Technology Information
  • Track 4-2Designer TALEN Technology Information
  • Track 4-3High-throughput functional genomics using CRISPR–Cas9
  • Track 4-4Improving genome editing with drugs
  • Track 4-5CRISPR mRNA and protein

As name "Integrative Biology" reflects conviction that the investigation of biological systems is best drawn nearer by fusing numerous points of view. We unite assorted qualities of controls that supplement each other to disentangle the complexity of biology. The idea incorporates anatomy, physiology, cell and stem cell biology, molecular biology, developmental biology, biochemistry and biophysics. We work with animals, plants and microorganisms and our exploration traverses the levels of the organic chain of command from molecules to ecosystems. Our expansive scope of mastery incorporates: geneticists, paleontologists, physiologists, behaviorists, systematists, morphologists, microbiologists, bioinformatician, evolutionary biologists, ecologists, biophysicists and biotechnologists.

  • Track 5-1Computational Bio modeling
  • Track 5-2Computational Genomics
  • Track 5-3Computational Neuroscience
  • Track 5-4Computational Pharmacology
  • Track 5-5Computational Evolutionary biology
  • Track 5-6Cancer Computational Biology

Biomaterials play a pivotal role in field of tissue engineering. Biomimetic synthetic polymers have been created to elicit specific cellular functions and to direct cell-cell interactions both in implants that are initially cell-free, which may serve as matrices to conduct tissue regeneration, and in implants to support cell transplantation. Biomimetic approaches have been based on polymers endowed with bioadhesive receptor-binding peptides and mono- and oligosaccharides. These materials have been patterned in two- and three-dimensions to generate model multicellular tissue architectures, and this approach may be useful in future efforts to generate complex organizations of multiple cell types.

  • Track 6-1Bone Tissue Engineering
  • Track 6-2Cartilage Tissue Engineering
  • Track 6-3Osteochondral in Tissue Engineering
  • Track 6-4Scaffolds in Tissue Engineering

Tissue engineering along with regenerative medicine can be used to create ‘Scaffolds’ in the human body. These scaffolds are used to support organs and organ systems that may have been damaged after injury or disease. This is most commonly achieved through the use of stem cells. Stem cells are unique types of cells that are undifferentiated. So the main focus of creating these constructs is to be able to safely deliver these stem cells, and create a structure that is physically and mechanically stable so that these stem cells can differentiate. Scaffolds are of great importance in clinical medicine. It is an upcoming field, and usually associated with conditions involving organ disease or failure. It is used to rebuild organs and return normal function.

  • Track 7-1Analogous functions of scaffolds and extracellular matrix
  • Track 7-2Scaffolding approaches in tissue engineering
  • Track 7-3Cell encapsulation in self-assembled hydrogel matrix
  • Track 7-4Scaffolding in intervertebral disc tissue engineering

The term “repair,” when used in the context of the healing of damaged tissue, is defined as the restoration of tissue architecture and function after an injury. It encompasses two separate processes: regeneration and replacement. Regeneration refers to a type of healing in which new growth completely restores portions of damaged tissue to their normal state. Replacement refers to a type of healing in which severely damaged or non-re generable tissues are repaired by the laying down of connective tissue, a process commonly referred to as scarring. While a few types of tissue injury (such as minor paper cuts) can sometimes be healed in such a way that no permanent damage remains, most of our tissue repair consists of both regeneration and replacement. Tissue repair may restore some of the original structures of the damaged tissue (such as epithelial layers), but may also result in structural abnormalities that impair organ function (such as the scar formed in the healing of a myocardial infarction).

  • Track 8-1Wound repair and injury-induced signaling
  • Track 8-2Anti- and pro-regenerative immune responses
  • Track 8-3Anti- and pro-regenerative immune responses
  • Track 8-4Biomechanical and bioelectrical control of regeneration
  • Track 8-5Blastema dynamics and tissue remodeling
  • Track 8-6Cell plasticity in heart regeneration
  • Track 8-7Regeneration of the CNS
  • Track 8-8Senescence, regeneration and ageing
  • Track 8-9Emerging trends of regeneration research

Synthetic biology has pioneered transformative approaches that are affecting how scientists tackle key questions in mammalian cell biology. Synthetic biology techniques have wide-ranging applicability and commonly make use of genetic devices, or collections of genetic elements encoding particular functions, for probing key cellular mechanisms. Early success focused on engineered transcription-based regulatory systems primarily in bacteria. More recently, new endeavors have shifted to mammalian gene regulatory processes to allow flexible, precise, and comprehensive control over gene expression and cellular development. Novel and more complex genetic devices have been used to probe cellular mechanisms, including alternative splicing, RNAi, and epigenetics.

  • Track 9-1Production of Natural products from synthetic biology
  • Track 9-2Production of Bio-Fuels, Chemicals and Pharmaceuticals
  • Track 9-3Industry Uses of Synthetic Biology
  • Track 9-4Industrial Production of Green Chemicals
  • Track 9-5Therapeutic Cells

Synthetic Bioengineering is the manipulation of the biological compounds varying their physical and chemical forms using engineering principles and techniques. Engineering is done at cellular and subcellular level i.e. molecular level. Bioengineering is the “biological or medical application of engineering principles or engineering equipment. Recently, the practice of bioengineering has expanded beyond large-scale efforts like prosthetics and hospital equipment to include engineering at the molecular and cellular level with applications in energy and the environment as well as healthcare

  • Track 10-1Molecular, Cellular and Tissue Engineering
  • Track 10-2Stem Cell Engineering
  • Track 10-3Bioprocessing Engineering
  • Track 10-4Single cell Imaging
  • Track 10-5Single cell Imaging
  • Track 10-6Biomedical Engineering

Synthetic biotechnology involves the manipulation of biological compounds like integration of synthetic aminoacids into proteins, DNA synthesis and manipulation using synthetic sequences, oligonucleotide synthesis, protein modification using synthetic compounds etc. the compounds produced synthetically are orthogonally integrated into cells which are chosen to provide suitable experimental strategy.

Synthetic biology represents a convergence of advances in chemistry, biology, computer science, and engineering. systematic methods for increasing the speed, scale, and precision with which we engineer biological systems. In a sense, synthetic biology can be thought of as the development of a biology-based “toolkit” that enables improved products across many industries, including medicine, energy and the environment.The manipulations in the wild type system by the engineered systems are studied varying their efficiency

  • Track 11-1Biotechnology and Biomaterials
  • Track 11-2Bioprocessing and Biotechniques
  • Track 11-3Chemical Engineering and Chemical Sciences
  • Track 11-4Nanomedicine, Artifiicial Cells and Biochemical Engineering
  • Track 11-5Biochemistry and Synthetic Biotechnology

There are a large number of reports on gene therapy in tissue engineering, and these cover a huge range of different engineered tissues, different vectors, scaffolds and methodology. The review considers separately in-vitro and in-vivo gene transfer methods. The in-vivo gene transfer method is described first, using either viral or non-viral vectors to repair various tissues with and without the use of scaffolds. The use of a scaffold can overcome some of the challenges associated with delivery by direct injection. The ex-vivo method is described in the second half of the review. Attempts have been made to use this therapy for bone, cartilage, wound, urothelial, nerve tissue regeneration and for treating diabetes using viral or non-viral vectors. Again porous polymers can be used as scaffolds for cell transplantation. There are as yet few comparisons between these many different variables to show which is the best for any particular application. With few exceptions, all of the results were positive in showing some gene expression and some consequent effect on tissue growth and remodeling

  • Track 12-1Future Direction of Gene Therapy in Tissue Engineering
  • Track 12-2Gene Therapy for Bone Engineering
  • Track 12-3Growth Factors and Tissue Healing

Synthetic genomics is an early field of engineered science that uses parts of hereditary alteration on prior life frames with the plan of delivering some item or wanted conduct with respect to the living thing so made.Synthetic genomics joins strategies for the fake amalgamation of DNA with computational methods to plan it. These strategies permit researchers and specialists to build hereditary material that would be inconceivable or illogical to deliver utilizing more routine biotechnological approaches. For instance, utilizing manufacturedgenomics it is conceivable to outline and amass chromosomes, qualities and quality pathways, and even entire genomes

  • Track 13-1Computational Genomics
  • Track 13-2Synthetic gene pathways
  • Track 13-3Regenomics
  • Track 13-4BioBrick
  • Track 13-5Functional genomics
  • Track 13-6Cheminformatics and Immunomics
  • Track 13-7BioBrick

Tissue engineering is a branch of regenerative medicine, itself a branch of biomedical engineering. Tissue engineering and regenerative medicine are concerned with the replacement or regeneration of cells, tissues (the focus of tissue engineers) or organs to restore normal biological function.

  • Track 14-1Multiscale technologies for treatment of ischemic cardiomyopathy
  • Track 14-2Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue
  • Track 14-3Controlling Adult Stem Cell Behavior Using Nanodiamond-Reinforced Hydrogel
  • Track 14-4The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform

Bone tissue engineering is a complex and dynamic process that initiates with migration and recruitment of osteoprogenitor cells followed by their proliferation, differentiation, matrix formation along with remodeling of the bone. The regenerative potency of bone is due to bone morphogenetic proteins (BMPs) in the bone matrix. BMPs act via BMP receptors and Smads 1, 5 and 8 to initiate lineage of cartilage and bone. The homeostasis of tissue engineered bone and cartilage is dependent on the maintenance of extracellular matrix and biomechanics.

  • Track 15-1Functional Tissue Engineering of Bone: Signals and Scaffolds
  • Track 15-2Optimization of Bone Scaffold Engineering for Load Bearing Applications
  • Track 15-3Bone Regeneration of the Cranio-maxillofacial and Dento-alveolar Skeletons in the Framework of Tissue Engineering
  • Track 15-4Scaffold Matrices for Bone Regeneration

Collagens are main protein components in natural cartilage, bone, and other connective tissue ECMs. They contribute to cell adhesion, proliferation and differentiation, 143 and, thus serve as one of the most common scaffold materials for cartilage tissue engineering.

  • Track 16-1Fibro chondrocytes and Their Use in Tissue Engineering of the Meniscus
  • Track 16-2Differentiation Factors and Articular Cartilage Regeneration
  • Track 16-3In Vitro and in Vivo Comparison of 4 Different Matrix Systems for Chondrocyte Transplantation
  • Track 16-4Injectable Hydrogels for Cartilage Tissue Engineering

Next-generation sequencing alludes to non-Sanger-based high-throughput DNA sequencing technologies. Millions or billions of DNA strands can be sequenced in parallel, yielding considerably more throughput and minimizing the requirement for the fragment cloning techniques that are frequently utilized as a part of Sanger sequencing of genomes. DNA sequencing industry is sectioned into instruments and consumables, administrations, and workflow products.

  • Track 17-1Identification, expansion and testing of the BAC clone
  • Track 17-2Mathematical modeling of cellular systems
  • Track 17-3Modeling and optimization
  • Track 17-4Computational Genomics

Stem cells will be cells begin in all multi-cell organisms. They were detached in mice in 1981 and in people in 1998. In people there are a few sorts of stem cells, each with variable levels of strength. Stem cell treatments are a sort of therapy that brings new cells into grown-up bodies for conceivable treatment of cancer, diabetes, neurological disorders and other medical conditions. Stem cells have been utilized to repair tissue damaged by infection or age. In a creating embryo, stem cells can separate into all the specific cells ectoderm, endoderm and mesoderm, additionally keep up the ordinary turnover of regenerative organs, for example, blood, skin, or intestinal tissue.

  • Track 18-1Synthetic Biochemistry
  • Track 18-2Synthetic organic chemistry
  • Track 18-3Green chemistry
  • Track 18-4Industrial production of Mobilized and Immobilized enzymes
  • Track 18-5Industrial Waste management

Natural cell phenotypes in tissues and organs are the result of stem cell differentiation at the embryonic stage of development. Although in vivo many natural biochemical/molecular biological determinants that instruct the direction of stem cell differentiation are well known (6, 7), very many cell types are also subject to native mechanical forces which also play a role in their phenotypic outcome. The source of stem cells may be either embryonic or adult (umbilical cord blood stem cells are generally classified as ‘adult’ though clearly a more appropriate term is sought). They should be either pluripotent, able to differentiate into cell types characteristic of any of the three developmental germ layers, or at least multipotent, capable of differentiating into varieties of an individual cell lineage.

  • Track 19-1Identifying stem cells
  • Track 19-2Embryonic stem cells
  • Track 19-3Cord blood cells
  • Track 19-4Adult stem cells and epithelial stem cells

A bioreactor can be defined as a device that uses mechanical means to influence biological processes. In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This chapter discusses the necessity for bioreactors in tissue engineering, the numerous types of bioreactor that exist, the means by which they stimulate cells and how their functionality is governed by the requirements of the specific tissue being engineered and the cell type undergoing stimulation.

  • Track 20-1Design of Bioreactors for Cardiovascular Applications
  • Track 20-2Micro Fluid Dynamics in Three Dimensional Engineered Cell Systems in Bioreactors
  • Track 20-3Mechanotransduction bioreactors

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. In precise usage this is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise. The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease

  • Track 21-1Angiogenesis
  • Track 21-2Adult bone marrow mesenchymal stem cells
  • Track 21-3Fibroblasts
  • Track 21-4Collagen