Explora Biotech Srl, Italy
Title: Empowering computer-assisted biological design by using in vivo characterized standard biological parts
Biography: Davide De Lucrezia
With synthetic biology, we can now design and construct new biological parts, devices and systems in a rational and systematic way. The application of forward engineering approach to biology necessarily requires the implementation of two fundamental design principles: 1) the use of standardized biological parts; and 2) the development of multi-scale predictive models to aid system engineering design. The author will report the latest results of our ongoing efforts to develop a comprehensive and highly integrated toolkit to exploit the full potential of synthetic biology based on: Comprehensive in vivo characterization of BioBricks and devices within the context of the host organism and under variable experimental settings to achieve a context-related description of part/device dynamics and performance; Development of a computer aided design tools (CAD) for biological engineering capable to support both design and simulation on multiple hierarchical levels. The hallmark is the deployment of a modeling platform that allow the multi-scale description of biological systems combining currently available algorithms and exploiting different modeling paradigms (e.g. continuous-deterministic models, probabilistic graphical models, discrete dynamical networks, P-systems) according to the scale under investigation.