Synthetic Biology

Biography

Biography: Abhishek Kundu

Abstract

Medicinal value of plants has been significantly rewarded by Indian research background, although ancient reports based screening has been enormously persuaded. Based on the experimental evidences and statistical screening many interesting physiological properties were shown by Indian medicinal plants resulting in the isolation of clinically useful compounds. The target of a pharmacologist is to find out a significantly effective compound of better activity with negligible or no side effects. Modification of the existing drugs or by discovering a lead compound can help to achieve the goal. Active engagement in the evaluation of Indian medicinal plants used in traditional medicinal system, over the last few years have discovered that the plant Pluchea indica (L.) Less root possesses anti-inflammatory, anti-ulcer and anti-oxidant properties. The present study involves the evaluation of some pharmacological activities, i.e. antimalarial, antimicrobial and antileishmanial both in-vitro and in-vivo by employing the tissue cultured P. indica root extract,PITC-2 (isolated compound) and its derivatives. As our previous study indicates, it is safe to use in biological system as it possesses a wide range of therapeutic window.PITC2 may be a potential lead to design a new drug against MDR malaria strains. It may be concluded that PITC-2 was not only an active antibacterial agent but also is able to interfere with and restrict the action of polymerase chain reaction for rebuilding of new DNA strands.The antileishmanial activity of the crude extract, PITC-2 and its derivative proved to be rather significant and promising as well with the IC50 values of < 20µg/ml