Tissue repair and Regeneration

The term “repair,” when used in the context of the healing of damaged tissue, is defined as the restoration of tissue architecture and function after an injury. It encompasses two separate processes: regeneration and replacement. Regeneration refers to a type of healing in which new growth completely restores portions of damaged tissue to their normal state. Replacement refers to a type of healing in which severely damaged or non-re generable tissues are repaired by the laying down of connective tissue, a process commonly referred to as scarring. While a few types of tissue injury (such as minor paper cuts) can sometimes be healed in such a way that no permanent damage remains, most of our tissue repair consists of both regeneration and replacement. Tissue repair may restore some of the original structures of the damaged tissue (such as epithelial layers), but may also result in structural abnormalities that impair organ function (such as the scar formed in the healing of a myocardial infarction).

  • Wound repair and injury-induced signaling
  • Anti- and pro-regenerative immune responses
  • Anti- and pro-regenerative immune responses
  • Biomechanical and bioelectrical control of regeneration
  • Blastema dynamics and tissue remodeling
  • Cell plasticity in heart regeneration
  • Regeneration of the CNS
  • Senescence, regeneration and ageing
  • Emerging trends of regeneration research

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