After completion of his postdoctoral training at University of Texas MD Anderson Cancer Center, Dr. Gautam Sethi joined Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore in 2008 as an Assistant Professor and was promoted to Associate Professor in 2015. The focus of his research over the past few years has been to elucidate the mechanism (s) of activation of oncogenic transcription factors such as NF-kB/STAT3 by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted in more than two hundred scientific publications in high impact factor peer reviewed journals (with h index = 68) and several international awards. He currently serves as an Academic Editor for PLOS, editorial board member of Scientific Reports, Cancer Letters, Pharmacological Research, BMC Cancer, Frontiers in Pharmacology, Frontiers in Oncology, Journal of Natural Products in Cancer Prevention and Therapy, and ad-hoc reviewer for several other prestigious international journals.
Mechanism(s) of regulation of oncogenic transcription factors by carcinogens and inflammatory agents. Identification of novel pharmacological compounds that can suppress activation of these transcription factors. Development and characterization of orthotopic/transgenic and xenograft mouse models of cancer.
Dr. Liang Yang is the Deputy Research Director for the Public Health and Medical Biofilm Cluster of Singapore Centre for Environmental Life Sciences Engineering (SCELSE). SCELSE is one of the world’s leading biofilm research institutes supported by the National Research Foundation and the Ministry of Education of Singapore under its Research Centre of Excellence Programme. Dr. Yang’s research is dedicated to bacterial biofilm drug resistance, interspecies communications, adaptive evolution and host-pathogen interactions. Dr. Yang has published 80 plus peer-reviewed research articles with a total citation more than 4,000 times according to google scholar. Dr. Yang has been awarded the FEMS Congress Grant for Young Scientist, Alexander von Humboldt Research Fellowship and the Elite Nanyang Assistant Professorship.
Microorganisms mainly live as highly organized surface-associated biofilm communities encased within extracellular matrices in nature. In the biofilm mode of life microbial cells communicate and interact with each other to coordinate functional group activities including defense against hazardous environment stress, and exchange of genetic material. Biofilms are extremely resistant to antimicrobial agents and physical stress and cause a wide range of problems to industrial and hospital settings. The National Institute of Health (NIH) in the US estimates that 65-80% of microbial infections occurring in the human body are biofilm-mediated. My research is dedicated to understanding intercellular signaling, interspecies interactions, and microbial evolution in the context of the biofilm lifestyle. At the fundamental level, both environmental stress and host immune-derived stress are examined for their impacts on inducing bacterial intercellular (quorum sensing) and intracellular (c-di-GMP) signaling mechanisms that coordinate biofilm formation and stress resistance. The combination of molecular biology and systems biology tools (transcriptomics and proteomics) has enabled us to examine how quorum sensing and c-di-GMP signaling mediate stress response in mono-species and multiple-species biofilms. At the applied level, high-throughput screening tools have been developed for discovering active compounds that can impair bacterial quorum sensing and c-di-GMP signaling. In addition, quorum sensing and c-di-GMP signaling are also being manipulated for improving the performance of industrial related bioreactors such as the microbial fuel cells. At the translational level, clinical isolates of major nosocomial infection causing species are monitored for their antibiotic resistance and genome contents. Comparative genomics and experimental evolution experiments are further employed to identify adaptive evolution of pathogens during chronic biofilm-associated infections.