Mammalian Synthetic Biology (Human Artificial Chromosomes)

Scientists tend to engineer human cells to remember past events and perform specific functions as a result. These systems are both transcriptional and post-transcriptionally driven. This includes cells that respond to drugs, disease states and the environment. We also develop novel ways to target cells with potentially therapeutic proteins with an emphasis on cells of the immune system and cancer. We develop computer simulations to model these systems.
 
Tools and approaches for studying molecular mechanisms in mammalian cells

  • Alternative splicing
  • RNAi
  • Epigenetic regulation
  • Signaling pathways

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